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Pifithrin-α Hydrobromide

SKU
P-1177
  • CAS:63208-82-2
  • Formula:C16H18N2OS • HBr
  • MW:367.30 Da
  • Appearance:Off-white solid
  • Purity:>98%
Product Name Qty
Pifithrin-α Hydrobromide
10 mg
$114.21
Pifithrin-α Hydrobromide
25 mg
$256.36
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Description

Pifithrin-α Hydrobromide is a chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. It reversibly blocks p53 dependent transcriptional activation and apoptosis.

References

• p53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition
• p53 Down-Regulates Phosphatase and Tensin Homologue Deleted on Chromosome 10 Protein Stability Partially through Caspase-Mediated Degradation in Cells with Proteasome Dysfunction
• Histone Deacetylase Inhibitor-Mediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53
• Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Pifithrin-alpha; Pifithrin-alpha hydrobromide; PFT-alpha; PFT-α
SKU
P-1177
CAS #
63208-82-2
Chemical Name
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
Chemical Formula
C16H18N2OS • HBr
Molecular Weight
367.30 Da
Appearance
Off-white solid
Purity
>98%
Solubility
Soluble in DMSO, DMF, Methanol
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis
MDL NUMBER
MFCD00417851
CHEMACX
X1343322-2
INCHI
InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
SMILES
Cc1ccc(cc1)C(=O)Cn2c3c(sc2=N)CCCC3.Br
Handling
Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Handle in accordance with good industrial hygiene and safety practice.
Certificate of Analysis 1
P-1177, C1093A.pdf
Certificate of Analysis 2
P-1177, C1093.pdf
Certificate of Analysis 3
P-1177, A10071.pdf
HandlingCorrosive hazard. Wear protective gloves/clothing and eye/face protection. Handle in accordance with good industrial hygiene and safety practice.
CitationsThe modulation of apoptosis in testicular germ cells following toxicant-induced cellular stress
Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure
Auswirkungen von Erythropoetin (ERYPO® 2000), p53 Inhibitor (pifithrin-alpha®) und TNF-∝ Inhibitor (Remicade®) auf das ZNS unter Bestrahlung, sowie immunhistochemische Untersuchungen im Hinblick auf DNADoppelstrangbrüche der bestrahlten Regionen. Eine tierexperimentelle Studie.
Association rule mining of cellular responses induced by metal and metal oxide nanoparticles
Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53
p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction
Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells
Molecular Mechanisms of Dopaime Receptor Mediated Neuroprotection
Hyperglycemia alters renal cell responsiveness to pressure in a model of malignant hypertension
Expression of the Bcl-3 proto-oncogene suppresses p53 activation
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress
Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2
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