Pifithrin-α Hydrobromide

SKU

P-1177

CAS:63208-82-2
Formula:C₁₆H₁₈N₂OS • HBr
MW:367.30 Da
Appearance:Off-white solid
Purity:>98%

SDS

CofA

Product Name	Qty
Pifithrin-α Hydrobromide 25 mg $250.59
Pifithrin-α Hydrobromide 10 mg $111.64

Details

Description

Pifithrin-α Hydrobromide is a chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. It reversibly blocks p53 dependent transcriptional activation and apoptosis.

References

• p53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition
• p53 Down-Regulates Phosphatase and Tensin Homologue Deleted on Chromosome 10 Protein Stability Partially through Caspase-Mediated Degradation in Cells with Proteasome Dysfunction
• Histone Deacetylase Inhibitor-Mediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53
• Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress

Not for human therapeutic use or for medicinal purposes. For research applications only.

Specifications

More Information

Alternate Name/Synonyms

Pifithrin-alpha; Pifithrin-alpha hydrobromide; PFT-alpha; PFT-α

SKU

P-1177

CAS #

63208-82-2

Chemical Name

1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide

Chemical Formula

C₁₆H₁₈N₂OS • HBr

Molecular Weight

367.30 Da

Appearance

Off-white solid

Purity

>98%

Solubility

Soluble in DMSO, DMF, Methanol

Storage Temp

-20°C

THERAPEUTIC AREA

Oncological Disorders

USE

An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis

MDL NUMBER

MFCD00417851

CHEMACX

X1343322-2

INCHI

InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H

SMILES

Cc1ccc(cc1)C(=O)Cn2c3c(sc2=N)CCCC3.Br

Handling

Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Handle in accordance with good industrial hygiene and safety practice.

Certificate of Analysis 1

P-1177, C1093A.pdf

Certificate of Analysis 2

P-1177, C1093.pdf

Certificate of Analysis 3

P-1177, A10071.pdf

Reviews

Safety

Handling	Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Handle in accordance with good industrial hygiene and safety practice.

Citations

Citations	The modulation of apoptosis in testicular germ cells following toxicant-induced cellular stress
	Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure
	Auswirkungen von Erythropoetin (ERYPO® 2000), p53 Inhibitor (pifithrin-alpha®) und TNF-∝ Inhibitor (Remicade®) auf das ZNS unter Bestrahlung, sowie immunhistochemische Untersuchungen im Hinblick auf DNADoppelstrangbrüche der bestrahlten Regionen. Eine tierexperimentelle Studie.
	Association rule mining of cellular responses induced by metal and metal oxide nanoparticles
	Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53
	p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction
	Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells
	Molecular Mechanisms of Dopaime Receptor Mediated Neuroprotection
	Hyperglycemia alters renal cell responsiveness to pressure in a model of malignant hypertension
	Expression of the Bcl-3 proto-oncogene suppresses p53 activation
	p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
	Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress
	Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity
	Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
	The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2