Pifithrin-μ

SKU
P-2723
  • CAS:64984-31-2
  • Formula:C8H7NO2S
  • MW:181.2 Da
  • Appearance:Solid
Product Name Qty
Pifithrin-μ
10 mg
$100.25

Description

Pifithrin-μ is a cell-permeable sulfonamide inhibitor of p53 binding and an anti-apoptotic. Direct inhibition of p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins by Pifithrin-μ has been observed. Pifithrin-μ selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.

Pifithrin-μ has been shown to reduce γ-radiation induced cell death in vitro. Unlike pifithrin-α (sc-45050), pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53. Pifithrin-μ selectively inhibits HSP 70 (heat shock protein 70) activity.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
2-Phenylacetylenesulfonamide; NSC 303580; phenylethynesulfonamide
SKU
P-2723
CAS #
64984-31-2
Chemical Name
2-phenylethynesulfonamide
Chemical Formula
C8H7NO2S
Molecular Weight
181.2 Da
Appearance
Solid
Storage Temp
4°C
USE
An inhibitor of p53 activity and HSP 70 activity
MDL NUMBER
MFCD00181531
CHEMACX
X1561648-3
INCHI
InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
SMILES
c1ccc(cc1)C#CS(=O)(=O)N
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Hazard Image
Yes
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
To Top