Pifithrin-μ

SKU

P-2723

CAS:64984-31-2
Formula:C₈H₇NO₂S
MW:181.2 Da
Appearance:Solid

SDS

CofA

Product Name	Qty
Pifithrin-μ 10 mg $100.25

Details

Description

Pifithrin-μ is a cell-permeable sulfonamide inhibitor of p53 binding and an anti-apoptotic. Direct inhibition of p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins by Pifithrin-μ has been observed. Pifithrin-μ selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.

Pifithrin-μ has been shown to reduce γ-radiation induced cell death in vitro. Unlike pifithrin-α (sc-45050), pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53. Pifithrin-μ selectively inhibits HSP 70 (heat shock protein 70) activity.

Not for human therapeutic use or for medicinal purposes. For research applications only.

Specifications

More Information

Alternate Name/Synonyms

2-Phenylacetylenesulfonamide; NSC 303580; phenylethynesulfonamide

SKU

P-2723

CAS #

64984-31-2

Chemical Name

2-phenylethynesulfonamide

Chemical Formula

C₈H₇NO₂S

Molecular Weight

181.2 Da

Appearance

Solid

Storage Temp

4°C

USE

An inhibitor of p53 activity and HSP 70 activity

MDL NUMBER

MFCD00181531

CHEMACX

X1561648-3

INCHI

InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)

SMILES

c1ccc(cc1)C#CS(=O)(=O)N

Handling

Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.

Hazard Image

Yes

Reviews

Safety

GHS PICTOGRAMS
Handling	Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.

Citations