Piperlongumine

SKU
P-2399
  • CAS:20069-09-4
  • Formula:C17H19NO6
  • MW:317.34
  • Appearance:White to off-white Solid
  • Purity:97%

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Product Name Qty
Piperlongumine
10 mg
$67.21
Piperlongumine
50 mg
$226.67
A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.
More Information
Alternate Name/Synonyms
(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
SKU
P-2399
CAS #
20069-09-4
Chemical Name
(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Chemical Formula
C17H19NO6
Molecular Weight
317.34
Appearance
White to off-white Solid
Purity
97%
Solubility
DMSO (~ 25 mg/ml)
Melting Point
123-124 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A selective anticancer GSTP1 inhibitor
MDL NUMBER
MFCD00075706
CHEMACX
X1095211-1
INCHI
InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
SMILES
COc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O
Peptide sequence
Not Applicable
RTECS
UU7785850
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
Handling Protect from light and air
UN #'S Not Applicable
Packing Group Not Applicable
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