PJ-34

SKU
P-1455
  • CAS:344458-15-7
  • Formula:C17H17N3O2•HCI
  • MW: 316.786 Da
  • Appearance:Light-brown powder
  • Purity:≥98%

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1

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Product Name Qty
PJ-34
1 mg
$61.42
PJ-34
5 mg
$150.77
PJ-34
25 mg
$362.93

Description

PJ-34 is a potent inhibitor of poly(ADP)-ribose polymerase that is capable of inducing mitotic arrest. Rat studies have demonstrated that PJ-34 can exert neuroprotective effects in cases of ischemic damage by modulating the RAGE receptor. PJ-34 has also demonstrated an antiplatelet effect in vitro, suggesting that it could have significant potential for improving repurfusion following strokes.

Considerable research has also been conducted into the anticancer effects of this compound. Through inhibition of PARP-1, PJ-34 has the capacity to enhance the effects of chemotherapy. Mouse studies have confirmed its ability to suppress the growth of cancerous cells and induce apoptosis. PJ-34 has even been shown to inhibit angiogenesis by blocking ordinary cellular signaling pathways associated with blood vessel formation.

More Information
Alternate Name/Synonyms
PJ34 hydrochloride; PJ34 HCl; PARP Inhibitor VIII, PJ34; AK127264; SCHEMBL5074001; N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
SKU
P-1455
CAS #
344458-15-7
Chemical Name
2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride
Chemical Formula
C17H17N3O2•HCI
Molecular Weight
316.786 Da
Appearance
Light-brown powder
Purity
≥98%
Solubility
Soluble in water or DMSO
Storage Temp
Store desiccated at +4 C. HYGROSCOPIC!
THERAPEUTIC AREA
Oncological disorders
USE
• PARP over-activation could allow NAD depletion and consequent necrosis, thus to an inflammatory condition in many diseases. The combined treatment of tumors with PARP inhibitors/anticancer agents proved to have a beneficial effect in cancer therapy. • PJ-34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer. • PARP inhibition blocks angiogenesis-related endothelial cells properties by interfering with multiple signalling pathways leading to the inhibition of new blood vessel formation.
MDL NUMBER
MFCD03452993
CHEMACX
X1343324-6
INCHI
InChI=1S/C17H16N2O2.ClH/c1-19(2)16(20)10-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(21)18-15;/h3-9H,10H2,1-2H3,(H,18,21);1H
SMILES
CN(C)C(=O)Cc1ccc2c(c1)c3ccccc3c(=O)[nH]2.Cl
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Thermal decomposition can lead to release of toxic/corrosive gases and vapors. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Thermal decomposition can lead to release of toxic/corrosive gases and vapors. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
UN #'S Not Applicable
Packing Group Not Applicable
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