Podophyllotoxin

SKU
P-3301
  • CAS:518-28-5
  • Formula:C22H22O8
  • MW:414.4
  • Appearance:White to off-white powder
  • Purity:≥98% by HPLC

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Product Name Qty
Podophyllotoxin
100mg
$49.67

Description

Podophyllotoxin is a potent microtubule assembly inhibitor. It has antineoplastic and apoptotic properties so it can be used as an anticancer reagent.

The toxin binds to topoisomerase II during the late S and early G2 stage. It interferes with tubulin polymerization and thus ultimately inhibits mitosis.

Podophyllotoxin derivatives such as etoposide, etopophos, and teniposide have been successfully utilized in the treatment of a variety of malignant conditions and have shown potent antiviral, immunosuppressive and cytotoxic properties as well.

 

Applications

• Microtubule assembly inhibitor

• Anticancer agent

• Apoptosis inducer

• DNA topoisomerase II inhibitor

• Antiviral and anthelmintic agent

 

References

• “Podophyllotoxin”

“Podophyllotoxin: Current Perspectives”

“Endophyte Fungal Isolates from Podophyllum peltatum Produce Podophyllotoxin”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Podofilox; Condylox; Condyline; Podophyllum; Warticon; Wartec; (-)-Podophyllotoxin; Podophyllotoxin 7; Podophyllum
SKU
P-3301
CAS #
518-28-5
Chemical Name
(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
Chemical Formula
C22H22O8
Molecular Weight
414.4
Appearance
White to off-white powder
Purity
≥98% by HPLC
Solubility
Soluble in chloroform, acetone, ethyl acetate or ethanol. Insoluble in water.
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological studies
USE
Anti-cancer, microtubule assembly inhibitor
Handling
Hygroscopic. Keep under inert gas. Protect from moisture.
GHS PICTOGRAMS
Handling Hygroscopic. Keep under inert gas. Protect from moisture.
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