38966-21-1
338.5
C20H34O4
Methanol: Clear colorless solution at 10 mg/ml
-20°C
Synonym: (1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
Description
Aphidicolin is a reversible inhibitor of nuclear DNA replication in eukaryotes and some animal viruses. It interferes with dCTP-specific binding sites on DNA polymerase-α. It also works on other DNA polymerases, however it does not work on DNA polymerase-β.
Viruses inducing DNA polymerase-α, such as Herpes simplex, can be affected by aphidicolin because of its mechanism. It could be used for clinical study.
Isolated from Nigrospora oryzae.
Applications
• Control of cell proliferation
• DNA pol-β studies
• Read More: Pathology Research Using Mitophagy Modulators
References
• • “Effect of aphidicolin on viral and human DNA polymerases”
• "DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene"
• "Structural basis for inhibition of DNA replication by aphidicolin"
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
