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Aphidicolin, 25 MG

Price$ 1,614.57
  • SKU: A-1026-25MG
  • Pack Size: 25 MG
Quantity
-
+

38966-21-1

338.5 Da

C20H34O4

Methanol: Clear colorless solution at 10 mg/ml

-20°C


Synonym: (1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol

Description

Aphidicolin is a reversible inhibitor of nuclear DNA replication in eukaryotes and some animal viruses. It interferes with dCTP-specific binding sites on DNA polymerase-α. It also works on other DNA polymerases, however it does not work on DNA polymerase-β.

Viruses inducing DNA polymerase-α, such as Herpes simplex, can be affected by aphidicolin because of its mechanism. It could be used for clinical study.

Isolated from Nigrospora oryzae.

 

Applications

• Control of cell proliferation

• DNA pol-β studies

• Read More: Pathology Research Using Mitophagy Modulators

 

References

• • “Effect of aphidicolin on viral and human DNA polymerases”

• "DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene"

• "Structural basis for inhibition of DNA replication by aphidicolin"

 

 

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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