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Blasticidin S HCl, 25 MG

Price$ 150.14
  • SKU: B-1247-25MG
  • Pack Size: 25 MG
Quantity
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Frequently Bought Together

Total price: $ 1,400.14

This item: Blasticidin S HCl, 25 MG $ 150.14

G-418 Sulfate, 100 G $ 1,250.00

Blasticidin S; Bla-S

3513-03-9

458.9

C17H26N8O5 • HCl

Water

-20°C


Description:

Blasticidin S HCl is an antibiotic that demonstrates a strong inhibitory effect on protein synthesis in eukaryotic and prokaryotic cells. Blasticidin causes tRNA to bond more strongly to the P site of the large ribosomal subunit while simultaneously deforming the tRNA, thus inhibiting proper translation. The ultimate result of this process is a significant suppression of the hydrolysis of peptidyl-tRNA along with inhibition of peptide bond formation. Isolated from Streptomyces griseochromogenes.
 

Applications:

Aside from its antibiotic effects, blasticidin can be used to select for blasticidin resistance genes, which have undergone considerable study in recent years. One resistance gene, blasticidin S deaminase, has been used as a selection marker for genetic transformation and genome editing. The antibiotic has also been used as a selection factor in studies of forced genetic expression in anticancer therapy, specifically of the CSR1 gene.

  • Used as a selection agent for bls, bsr, or BSD resistance genes 
  • Prevents cell culture contamination
  • Effective in antiviral, antitumor, and antifungal properties
  • New role in Genome editing utilizing the CRISPR/Cas9 system. 
  • Gene selection antibiotic

 

Blasticidin S HCl Solution (10 mg/mL) available here.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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