Carbecin; Microcillin; Pyocianil; Hyoper; Geopen; Pyopen; Fugacillin; Gripenin
Carbenicillin Disodium Salt is a penicillin-derived β-lactam antibiotic that interferes with cell wall synthesis, primarily in gram-negative bacteria such as Pseudomonas aeruginosa, while showing low toxicity to plant tissues.
Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal area by opening the lactam ring. This inactivation intercepts the cross-linkage of peptidoglycan strands, by impeding the third and last phase of bacterial cell wall synthesis. This prompts inadequate bacterial cell wall synthesis and causes cell lysis.
- Used in selection protocols over ampicillin due to its increased stability
- Used in genetic transformation applications to select for AmpR transformed cells
- Used to regulate bacterial growth in plants, yielding low regeneration frequencies
- Used as a gene selection antibiotic in plant biology utilizing the CRISPR/CAS9 system
Research or further manufacturing use only, not for food or drug use.