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Concanamycin B, 0.25 MG

Price$ 372.59
  • SKU: C-2661-0.25MG
  • Pack Size: 0.25 MG
Quantity
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+

81552-33-2

851.5 Da

C45H73NO14

Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

-20°C


Description

Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.

References

Structures of concanamycins B and C. Kinashi H. et al., J. Antibiot. 1982, 35, 1618.
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al., Biol. Pharm. Bull. 1996, 19, 297.
Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al., J. Antibiot. 1995, 48, 488.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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