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Curvularin, 1 MG

Price$ 67.81
  • SKU: C-2675-1MG
  • Pack Size: 1 MG
Quantity
-
+

10140-70-2

292.3

C16H20O5

Soluble in methanol, dioxane, pyridine

-20°C


Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

*Please inquire the availability for this product.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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