G418; Geneticin; Glycoside-418 Sulfate
C20H40N4O10 • 2H2SO4
G-418 Sulfate is an aminoglycoside antibiotic that is synthesized from Micromonospora rhodorangea and functions by causing a chain of nonsense mutations during translation.
Due to translation G-418 inhibited polypeptide synthesis and protein elongation. G-418 binds to the 80S subunit of the ribosome by blocking the elongation phase of protein synthesis, both in prokaryotic and eukaryotic cells. It also shows activity against protozoa, cecal amoebiasis, and helminthes.
- Used routinely in molecular genetics experiments for selecting eukaryotic transformants
- Used in plant and mammalian cell culture as a selectable marker
- Used as a gene selection antibiotic that has a powerful new role in genome editing, utilizing the CRISPR/CAS9 system.
- Ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro
Research or further manufacturing use only, not for food or drug use.