71827-03-07
875.1 Da
C48H74O14
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
-20°C
Description
Ivermectin B1a (dihydroavermectin B1a) is the major component (>80%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides. The individual 25-sec-butyl (B1a) and 25-iso-propyl (B1b) components of ivermectin have received little separate study.
References
• Ivermectin, a new broad-spectrum antiparasitic agent
• Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics
• Avermectin\milbemycin resistance in trichostrongyloid nematodes
• Ivermectin: a potent new antiparasitic agent
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
