680571-51-1
809.8
C41H47NO16
Soluble in ethanol, methanol, DMSO, and DMF
-20°C
*Please inquire the availability for this product. Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
