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Leptomycin A, 1 MG

Price$ 458.99
  • SKU: L-2533-1MG
  • Pack Size: 1 MG


526.70 Da


Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.


Description & Applications

Leptomycin A is a compound that, along with the better-known leptomycin B analogue, makes up the broader leptomycin complex produced by some Streptomyces species. Leptomycin B is a documented inhibitor of CRM1 and as a result is capable of significantly inhibiting nuclear export.

Leptomycin B also demonstrates a cytotoxic effect that is more pronounced in cancerous cells than in those functioning normally. This effect has led to research into leptomycin B as a potential therapy for lung cancer. As a closely related member of the complex, leptomycin A is likely to exert the same inhibitory effect on nuclear export. Leptomycin A has also been shown to have some effectiveness as an antifungal agent. Leptomycin A shows antimicroMSTl activity against Schizosaccaromyces pombe and Mucor rouxianus.

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs

Research or further manufacturing use only, not for food or drug use.

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