87081-35-4
540.7 Da
C33H48O6
Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
-20°C
Description
Leptomycin B is an antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathway. It also demonstrates anti-fungal anti-tumor activity.
Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal, antibacterial and potent antitumor activities.
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
