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Leucinostatin A, 0.5 MG

Price$ 344.12
  • SKU: L-2539-0.5MG
  • Pack Size: 0.5 MG


1218.6 Da


Soluble in ethanol, methanol, DMF, DMSO, and water (limited).




Leucinostatin A is the major component of atypical nonapeptide complex and a fungal metabolite isolated from Paecilomyces lilacinus.

Leucinostatins show broad bioactivity against Gram-positive bacteria, fungi, plants and tumor cell lines. It inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin.

It is believed that leucinostatin A suppresses the activation of T lymphocytes. It acts as a weak ionophore facilitating the transport of mono- and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes.

It has been reported that it has an activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.



• Antibiotic

• Ionophore

• Immunosuppressive agent



• “The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes”

• “Leucinostatin A inhibits prostate cancer growth through reduction of insulin‐like growth factor‐I expression in prostate stromal cells”

• “In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin”


Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs

Research or further manufacturing use only, not for food or drug use.

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