Quick Order Pad
Your Shopping Cart is Empty
Hello, Sign In

Leucinostatin A, 0.5 MG

Price$ 344.12
  • SKU: L-2539-0.5MG
  • Pack Size: 0.5 MG
Quantity
-
+

76600-38-9

1218.6 Da

C62H111N11O13

Soluble in ethanol, methanol, DMF, DMSO, and water (limited).

-20°C


INQUIRE FOR PRICING & AVAILABILITY 

Description

Leucinostatin A is the major component of atypical nonapeptide complex and a fungal metabolite isolated from Paecilomyces lilacinus.

Leucinostatins show broad bioactivity against Gram-positive bacteria, fungi, plants and tumor cell lines. It inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin.

It is believed that leucinostatin A suppresses the activation of T lymphocytes. It acts as a weak ionophore facilitating the transport of mono- and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes.

It has been reported that it has an activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.

 

Applications

• Antibiotic

• Ionophore

• Immunosuppressive agent

 

References

• “The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes”

• “Leucinostatin A inhibits prostate cancer growth through reduction of insulin‐like growth factor‐I expression in prostate stromal cells”

• “In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

Product Recommendations