Soluble in ethanol, methanol, DMF, DMSO, and water (limited).
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Leucinostatin A is the major component of atypical nonapeptide complex and a fungal metabolite isolated from Paecilomyces lilacinus.
Leucinostatins show broad bioactivity against Gram-positive bacteria, fungi, plants and tumor cell lines. It inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin.
It is believed that leucinostatin A suppresses the activation of T lymphocytes. It acts as a weak ionophore facilitating the transport of mono- and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes.
It has been reported that it has an activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.
• Immunosuppressive agent
Not for human therapeutic use or for medicinal purposes. For research applications only.
Research or further manufacturing use only, not for food or drug use.