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Mitomycin C, 10 MG

Price$ 100.00
  • SKU: M-1108-10MG
  • Pack Size: 10 MG
Quantity
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Total price: $ 1,182.99

This item: Mitomycin C, 10 MG $ 100.00

Mitomycin C, 100 MG $ 650.00

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50-07-7

334.3

C15H18N4O5

Clear blue-violet solution at 10 mg/mL in DMSO or CH3OH

-20°C


Description

Mitomycin C is an alkylating agent produced from Streptomyces caespitosus. It has antitumor properties, inhibiting DNA synthesis and nuclear division of cancer cells, especially Ehrlich ascites tumor cells. It also activates both intrinsic and extrinsic pathways of apoptosis.

The agent specifically targets the guanine nucleoside sequence 5'-CpG-3'. It promotes DNA crosslinking and inhibits separation of complementary DNA strands. Because of this mechanism, it is most active from late G1 phase to S phase of cell cycle.

In addition, it is useful as an antibiotic for both Gram-negative and Gram-positive bacteria.

 

Applications

• Antibiotic

• Antitumor agent

• DNA crosslinking agent

Read more: Mitomycin C Applications in Life Sciences

 

References

“32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin”

• “Preferential Activation of Mitomycin C to Cytotoxic Metabolites by Hypoxic Tumor Cells”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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