C23H45N5O14 • H2SO4
Paromomycin sulfate is an aminoglycoside antibiotic effective against Gram-negative and Gram-positive bacteria, protozoa and cestodes. The antibiotic has a similar effect as neomycin.
Paromomycin binds to a highly conserved sequence, the A site, of the 16S rRNA of the 30S ribosomal subunit in bacteria. It induces a conformational change and thus interrupts translation and synthesis of protein and leads to cell death.
It has antiprotozoal properties and treats parasitic diseases such as Leishmaniasis.
• Aminoglycoside antibiotic
• Protein synthesis inhibitor
• Selective agent of oat transformation
• Assay: ≥ 675 U/mg
• Loss on Drying: ≤ 5.0%
• pH 3.0% Solution at 25°C: 5.0 - 7.5
• Specific Optical Rotation: +50.0 - +55.0°C
• “Use of paromomycin as a selective agent for oat transformation”
• “Ribosomal RNA Recognition by Aminoglycoside Antibiotics”
Not for human therapeutic use or for medicinal purposes. For research applications only.
Research or further manufacturing use only, not for food or drug use.