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Penicillic Acid, 10 MG

Price$ 126.63
  • SKU: P-1179-10MG
  • Pack Size: 10 MG
Quantity
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+

90-65-3

170.17

C8H10O4

Soluble in water

Room Temperature


Description

Penicillic acid is a potential antibiotic. It is carcinogenic and mutagenic by inducing DNA single strand breaks.

Penicillic acid is a mycotoxin isolated from Penicillium cyclopium and has known mutagenic and cytotoxic effects by arresting cell cycle in a metaphase and interrupting DNA synthesis.

It also irreversibly inactivates GMD (GDP-mannose dehydrogenase) which catalyzes GDP-mannuronic acid to alginate.

It has been reported that penicillic acid is a biologically active QSI (Quorum sensing inhibitory) compound and that neutrophils become activated when bacteria are treated with the acid.

 

Applications

• Antibiotics

• Used as an inactivator of GMD (GDP-mannose dehydrogenase)

• Used in quorum sensing studies

 

References

• “Characterization of GDP-mannose Dehydrogenase from the Brown Alga Ectocarpus siliculosus Providing the Precursor for the Alginate Polymer”

• “Inactivation of GDP-mannose dehydrogenase from Pseudomonas aeruginosa by penicillic acid identifies a critical active site loop”

• “Synthesis of the Antibiotic, Penicillic Acid”

• “Mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations by various mycotoxins"

• “Identity and effects of quorum-sensing inhibitors produced by Penicillium species” 

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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