Mixture of sulfates of polypeptides from certain strains of Bacillus polymixa. Active against gram negative bacteria.
Cell culture tested, Potency approximately 6500 units/mg.
The polymyxins are cationic peptides originally isolated from B. polymyxa.1 They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components.3,4 Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.4
EC Number: 215-774-7
Research or further manufacturing use only, not for food or drug use.