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Streptozotocin, 500 MG

Price$ 96.08
  • SKU: S-2044-500MG
  • Pack Size: 500 MG
Quantity
-
+

18883-66-4

265.2 Da

C8H15N3O7

Soluble in water, ethanol or DMSO at 50 mg/mL.

-20°C


Description

Streptozotocin is an antibiotic and related to DNA alkylation and methylation. Streptozotocin forms methylated purines that react with DNA in vitro. The methylating agent effects not only liver and kidney DNA, but also pancreatic DNA.

The antibiotic enters cells GLUT2 glucose transport protein and causes type I diabetes in rat models by beta-cell necrosis. It has been reported that Streptozotocin degenerates in Langerhans islet beta cells and thus induces diabetes in rodents.

Streptozotocin has anticancer properties and is used for several tumors such as leukemia, medullary thyroid carcinoma, and islet cell cancer of the pancreas.

 

Applications

• Type 1 diabetes inducer in rat models

• DNA alkylation and methylation

• Anticancer drug

 

References

• “Induction of diabetes by Streptozotocin in rats”

• “Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus”

• “Alkylation of DNA in Rat Tissues following Administration of Streptozotocin”

• “Using molecular dynamics simulation to explore the binding of the three potent anticancer drugs sorafenib, streptozotocin, and sunitinib to functionalized carbon nanotubes”

• “Pancreatic Islet Cell Carcinoma”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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