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Trinactin, 1 MG

Price$ 426.94
  • SKU: T-2657-1MG
  • Pack Size: 1 MG
Quantity
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+

7561-71-9

779.0 Da

C43H70O12

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

-20°C


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Description

Trinactin is a hydrophobic cyclic ester that acts as a member of the macrotetrolide complex isolated from Streptomyces aureus. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. It is used to help monovalent cations pass lipid membranes.

It acts as an antibiotic and affects oxidative phosphorylation in mitochondria. In a medium containing monovalent cation, trinactin induces hydrolysis of ATP and inhibition of tightly coupled respiration in mitochondria.

In addition, it is reported that the ionophore suppresses T-lymphocyte proliferation induced by IL-2 but without cell injury.

 

Applications

• Immunosuppressive agent

• Antibiotic

• Monovalent cation ionophore

 

References

• “Antibiotics As Tools for Metabolic Studies. V. Effect of Nonactin, Monactin, Dinactin, and Trinactin on Oxidative Phosphorylation and Adenosine Triphosphatase Induction”

• “Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats.”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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