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Valinomycin, 500 MG

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  • SKU: V-1013-500MG
  • Pack Size: 500MG

2001-95-8

1111.34

C54H90N6O18

Ethanol (50 mg/ml), DMSO (≥10 mg/ml), petroleum ether, ether, benzene, chloroform, glacial acetic, butyl acetate, and methanol (5 mg/ml).

-20°C


Description

Valinomycin is an antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium tuberculosis, and as an apoptosis inducer.

Isolated from Streptomyces fulvissimus.

 

Applications

Valinomycin is used diagnostically in ion selective electrodes because of its preferential ability to conduct K+ across the electrodes membrane. Valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) (both are present in the mitochondrial intermembrane space (MIS)) are released outside.

Valinomycin also inhibits hyphal growth in other dimorphic fungi, Candida tropicalis and Aureobasidium pullulan. It affects the morphology of Candida albicans.

 

Additional Reading: Pathology Research Using Mitophagy Modulators

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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