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Virginiamycin B, 5 MG

Price$ 450.00
  • SKU: V-2499-5MG
  • Pack Size: 5 MG
Quantity
-
+

3131-03-1

866.96

C45H54N8O10

Ethanol, Methanol, DMF, DMSO. Limited water solubility.

-20°C


Description

Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Virginiamycin B acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Virginiamycin B is a macrolide antibiotic. It inhibits the growth of Clostridium, Peptostreptococcus, and Propionibacterium bacterial species (MIC90s = 2, 0.5, and 8 μg/ml, respectively). It is inhibited its antibiotic function by erythromycin ribosome methylation genes interfering with Virginiamycin B binding.

Inquire for pricing on quantities >25 mg. 

 

Application

• Use as an antibiotic

• Inhibition of protein synthesis

 

Reference

• “Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants” 

• Inhibition of protein synthesis by streptogramins and related antibiotics

• Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms

 

Not for human therapeutic use or for medicinal purposes. For research applications only


0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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