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Allopregnanolone, 25 MG

Price$ 313.18
  • SKU: A-3000-25MG
  • Pack Size: 25 MG
Quantity
-
+

516-54-1

318.5 Da

C21H34O2

May be dissolved in DMSO (32 mg/mL); or Ethanol (32 mg/mL)

-20°C


Description

Allopregnanolone is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors1,2. Recently FDA approved (Brexanolone) for postpartum depression3. Inhibits TLR4 receptor activation and inflammatory signaling in macrophages and brain4. Inhibits glutamate release5 and displays neuroprotective effects in various animal models6.

 

References:

 

1. D Belelli and JJ Lambert Nat. Rev. Neurosci. 2005 6:565

2. DS Reddy et al. Prog. Brain Res. 2010 186:113

3. A Frieder et al. CNS Drugs 2019 33:265

4. I Balan et al. Sci. Rep. 2019 9:1220

5. Y Chang et al. Synapse 2019 73:e22076

6. I Cho et al. Neurochem. Res. 2018 43:1464

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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