DMSO (100 mM) or EtOH (50 mM)
An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd =10.3 μM). Binds exlusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate (Cat. No. 1609-1000), a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.
Research or further manufacturing use only, not for food or drug use.