Soluble in organic solvents such as DMSO and dimethyl formamide (DMF).
Synonym: 2-Amino-7-(1-methylethyl)-5-oxo-5H-benzopyrano[2,3-b]pyridine-3-carboxylic Acid
Amlexanox improves obesity-related metabolic dysfunction in mouse models. It increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1(TBK1) and IKKԑ (IC50=1.2 µM)².
Clinically useful in treatment of aphthus ulsers.
Amlexanox induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.
Research or further manufacturing use only, not for food or drug use.