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Amlexanox, 10 MG

Price$ 84.42
  • SKU: A-2431-10MG
  • Pack Size: 10 MG


298.3 Da


Soluble in organic solvents such as DMSO and dimethyl formamide (DMF).


Synonym: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid


Amlexanox improves obesity-related metabolic dysfunction in mouse models. It increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1(TBK1) and IKKԑ (IC50=1.2 µM)². 
Clinically useful in treatment of aphthus ulsers.

Amlexanox induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.


Product References
1. L Koch Nat. Rev. Endocrinol. 2013 9:185
2. SM Reilly et al. Nat. Med. 2012 19:313
3. L Matteo et al. J.Biol.Chem 2000 275:32573

0.1 lbs

Research or further manufacturing use only, not for food or drug use.