Quick Order Pad
Your Shopping Cart is Empty
Hello, Sign In

1-Hydroxy-2-pyridone, 2-Pyridinol-1-oxide

Price$ 132.68
  • SKU: H-2465-50GM
  • Pack Size: 50 G
1-Hydroxy-2-pyridone, 2-Pyridinol-1-oxide




N-Hydroxy compounds such as 1-hydroxybenzotriazole hydrate (HOBt) or 1-hydroxy-7-azabenzotriazole (HOAt) have traditionally been used in amide coupling reactions to suppress side reactions and minimise racemisation, the latter challenge being a key one in peptide synthesis. However, racemisation can still be an issue with either additive.

A recent change in the UN classification of HOBt resulting in more restrictive shipping regulations has led to interest in the lesser known alternative, 2-hydroxypyridine-N-oxide (HOPO).

2-Hydroxypyridine N-oxide is less frequently known by several other names: 2-hydroxypyridine 1-oxide, 2-pyridinol N-oxide, 2-Pyridinol 1-oxide, 1-hydroxypyridine-2-one, 1-hydroxy-2-pyridone and 1-hydroxy-2(1H)-pyridinone, 2-HPNO.
The major use for HOPO is in amide bond synthesis. A simple and efficient, biphasic (CH2Cl2 or EtOAc with water, 1:1) coupling protocol with EDC has been described, yielding di- or tri-peptides with low levels of racemisation, Scheme 1.5 HOPO had been previously used in a stepwise process via the initial formation of esters from activated amino acids (for example acid chlorides).

0.1 lbs

Research or further manufacturing use only, not for food or drug use.

Product Recommendations