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2-AMINO-2-(4-OCTYLPHENETHYL)PROPANE-1,3-DIOL HYDROCHLORIDE

Price$ 75.98
  • SKU: F-1162-5MG
  • Pack Size: 5 MG
Quantity
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2-AMINO-2-(4-OCTYLPHENETHYL)PROPANE-1,3-DIOL HYDROCHLORIDE

162359-56-0

343.9

C19H33NO2.HCl

Soluble in DMSO (10 mg / ml), 100% ethanol or Dimethyl formamide.

-20°C


FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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