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Rocaglamide, 100 UG

Price$ 416.09
  • SKU: R-2420-100UG
  • Pack Size: 100 UG
Quantity
-
+

84573-16-0

505.56

C29H31NO7

Soluble in DMSO or EtOH

-20°C


An immunosuppressant and a potent inhibitor of NF-B activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-, TNF, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-B and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.