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Paxilline, Penicillium paxilli, 5 MG

Price$ 156.78
  • SKU: P-1029-5MG
  • Pack Size: 5 MG
Quantity
-
+

57186-25-1

435.6

C27H33O4

Soluble in DMSO, ethanol, petrol ether

-20°C


Description

Paxilline is a tremorogenic indole diterpene and a potent, selective, and reversible inhibitor of high-conductance Ca2+-activated potassium (BKCa) channels in murine smooth muscle cells by stimulating binding of charybdotoxin (ChTX) to maxi-K channels and blocking the channels.

It is reported that a gain-of-function in BK-channel is related to spontaneous seizures in both animal models and humans. For example: epilepsy and paroxysmal movement disorder. Paxilline can cross the blood-brain barrier and downregulate the abnormal activity of gain-of-function in BK-channel.

 

Applications

• BK-channel antagonist

• Anticonvulsant reagent

• Neuronal diseases study

 

References

“Paxilline Inhibition of the Alpha-subunit of the High-conductance Calcium-activated Potassium Channel”

“Anticonvulsant effects of the BK‐channel antagonist paxilline”

“Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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