431.4
C22H25NO8
Soluble in methanol or ethyl acetate; poorly soluble in water
Pseurotin A isolated from Aspergillus fumigatus is reported to be a competitive inhibitor of chitin synthase and aninducer of nerve-cell proliferation. It is a useful model for adrenergic neuronal differentiation.
Pseurotin A presented low cytotoxicity towards human lung fibroblasts with IC50> or 1000 µM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 µg ml-1, respectively.
Pseurotin A inhibits IgE production in vitro and shows nematicidal activity.
Product References
Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus, Maiya S, et al., Chembiochem, 24;8(14):1736-43 (2007)
Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii., Schmeda-Hirschmann G, et al., Z Naturforsch C., 63(5-6):383-8 (2008)
Pseurotin A and its analogues as inhibitors of immunoglobuline E production, Minoru Ishikawa, et al., Bioorgainc&Medicinal Chemistry Lettters (2009)
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
