Pseurotin A isolated from Aspergillus fumigatus is reported to be a competitive inhibitor of chitin synthase and aninducer of nerve-cell proliferation. It is a useful model for adrenergic neuronal differentiation.

Pseurotin A presented low cytotoxicity towards human lung fibroblasts with IC₅₀> or 1000 µM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC₅₀ values of 220 and 112 µg m^l-1, respectively.

Pseurotin A inhibits IgE production in vitro and shows nematicidal activity.

Product References

• Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus, Maiya S, et al., Chembiochem, 24;8(14):1736-43  (2007)

• Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii., Schmeda-Hirschmann G, et al., Z Naturforsch C., 63(5-6):383-8  (2008)

• Azaspirene, Pseurotin A Key reactions

• Pseurotin A and its analogues as inhibitors of immunoglobuline E production, Minoru Ishikawa, et al., Bioorgainc&Medicinal Chemistry Lettters (2009)