N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine, sodium; ONO-5046
127373-66-4
456.4
C20H21N2O7S • Na
DMSO
Room Temperature
Sivelestat potent and selective leukocyte elastase inhibitor, IC50 = 44 nM. Displays no activity at a variety of other proteases. Inhibits NF-kB activation and LTB4-induced neutrophil migration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.
Research or further manufacturing use only, not for food or drug use.