(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one, hydrochloride
3039-71-2
424.1
C25H41NO2 • HCl
Water, DMSO
-20°C
U-18666A is a useful tool for inhibition of cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum. Inhibits cholesterol transport in a variety of cell types such as macrophages and sympathetic neurons. May be used to induce a Neimann-Pick disease type C (NPC) or NPC-like phenotype in a variety of cell types. Inhibits cholesterol biosynthesis at the level of oxido-squalene cyclase (OSC). Inhibits Deng virus entry and replication. Induction of cataracts is a common toxic feature of OSC inhibitors such as U-18666A.
Research or further manufacturing use only, not for food or drug use.
