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Ketanserin (tartrate), 50 MG

Price$ 123.02
  • SKU: K-1044-50MG
  • Pack Size: 50 MG
Quantity
-
+

83846-83-7

545.5

C22H22FN3O3 • C4H6O6

Soluble in Water, DMSO, and Ethanol

-20°C


Description

Ketanserin tartrate is a salt of Ketanserin and acts as a selective 5-HT2 receptor antagonist. It is also called R 41 468.

Ketanserin is a selective serotonergic antagonist. It inhibits effects of serotonin and displays high affinity for G protein coupled receptor (GPCR) and ion channels in the central nervous system (CNS). It has no agonistic property in isolated vascular preparation.

It was determined that Ketanserin tartrate has antihypertensive properties, inhibiting serotonin-induced platelet aggregation and causing either relaxation or contraction of vascular smooth muscle.

According to a study, Ketanserin tartrate inhibits HMG CoA reductase activity in human skin fibroblasts. Inhibition of HMG CoA reductase activity generally induces upregulation of LDL receptor activity.

In addition, it has been reported that it reduces systolic and diastolic blood pressure without alteration of heart rates and only affects to low density lipoprotein (LDL)-cholesterol level reduced.

 

Applications

• Used for hypertension

• Study of Serotonin pharmacology

 

References

• “Ketanserin”

• “Vascular Effects of Ketanserin (R 41 468), A Novel Antagonist of 5-HT2 Serotonergic Receptors”

• “Effects of Ketanserin Tartrate on Serum Lipids in Patients with Essential Hypertension”

• “Effects of ketanserin tartrate on 3-hydroxy, 3-methylglutaryl coenzyme a reductase activity in cultured human skin fibroblasts” 

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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