DMSO (25 mM) or Ethanol (25 mM)
Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC~ 5 M in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
Research or further manufacturing use only, not for food or drug use.