Soluble in DMSO (>10 mg/mL)
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1M Necrosis inhibitor 2 prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stressin vitro.
In vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress
In vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis
Ischemia Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis Acute Tubular Necrosis
Cell Media: Cell Therapy, CHO Growth
Research or further manufacturing use only, not for food or drug use.