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Necrosis Inhibitor-2, 1 MG

Price$ 124.22
  • SKU: N-1221-1MG
  • Pack Size: 1 MG
Quantity
-
+

516.67

C25H32N4O4S2

Soluble in DMSO (>10 mg/mL)

+4°C


Description

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1M Necrosis inhibitor 2 prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stressin vitro.

Applications

In vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress

In vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis

Ischemia Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis Acute Tubular Necrosis

Cell Media: Cell Therapy, CHO Growth

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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