TAE684
761439-42-3
614.2
C30H40ClN7O3S
DMF, DMSO
-20°C
NVP-TAE684 is a potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with IC= 2-10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK (Nucleophosmin-anaplastic lymphoma kinase) and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
