Soluble in DMSO (10 mg/mL), methanol (40 mg/mL), 0.1N sodium hydroxide (50 mg/mL) or acetic acid (camptothecin)
A cell-permeable, potent inhibitor of Beta-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an ICof 18 nM. It acts by disrupting the interaction betweencatenin and TCF4, possibly by direct binding to Beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
• Beta-catenin inhibitor
Research or further manufacturing use only, not for food or drug use.