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CRT Inhibitor, iCRT5, 5 MG

Price$ 99.34
  • SKU: C-2273-5MG
  • Pack Size: 5 MG
Quantity
-
+

18623-44-4

367.44

C16H17NO5S2

Soluble in DMSO (10 mg/mL), methanol (40 mg/mL), 0.1N sodium hydroxide (50 mg/mL) or acetic acid (camptothecin)

-20°C


Description

A cell-permeable, potent inhibitor of Beta-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an ICof 18 nM. It acts by disrupting the interaction betweencatenin and TCF4, possibly by direct binding to Beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.

 

Applications

• Beta-catenin inhibitor

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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