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GSK-J1, JMJ H3K27 Demethylase inhibitor (Non-cell permeable), 25 MG

Price$ 339.07
  • SKU: G-2641-25MG
  • Pack Size: 25 MG
Quantity
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+

1373422-53-7

389.46

C22H23N5O2

Soluble in DMSO (up to 20 mg/ml).

Room Temperature


GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such GSK-J1 is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available, see GSK-J4 (cat.# 10-1394).

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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