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Price$ 96.48
  • SKU: C-2547-5MG
  • Pack Size: 5 MG



C13 H8 N4 O S

Soluble in DMSO


PKR kinase inhibitor.

It is an imidazolo-oxindole derivative that has been shown to inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. The alpha subunit of the eukaryotic initiation factor 2 is phosphorylated by the PKR, which is an interferon-induced serine/threonine protein. PKR influences cytokine gene expression stimulated by the latent membrane protein 1 (LMP) in Epstein-Barr virus.

Research shows that PKR inhibitor inhibits the activities of caspase-3 and caspase-8 and prevents increase in pT(451)-PKR and pS(194)-FADD levels in SH-SY5Y nuclei. It has been observed that PKR inhibitor may protect cells against ER stress induced cell damage.

0.1 lbs

Research or further manufacturing use only, not for food or drug use.

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