DMSO (25 mg/ml) or EtOH (10 mg/ml)
Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC= 8 M)and cyclooxygenase (COX) (IC= 52 M). Also inhibits glutathione S-transferase,induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an ICof ~25 M. Does not affect p300/CREB binding protein-associated factor (PCAF).
Research or further manufacturing use only, not for food or drug use.