Soluble in DMSO (5 mg/ml), methanol (5 mg/ml) or methylene chloride
Elasnin isolated from Streptomyces sp. markedly inhibits human granulocyte elastase(IC50=1.3µg/ml), but it is almost inactive against pancreatic elastase, chymotrypsin(IC50=82µg/ml), and trypsin.
The culture also produced anti-candida activity. The specific action of elasnin is interesting in connection with its potential application to acute arthritis, various inflammations, pulmonary emphysema, and pancreatitis. Elasnin may facilitate a better understanding of these disease processes.
Elasnin is a neutral, colorless, and viscous oil.
Research or further manufacturing use only, not for food or drug use.