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Kifunensine, 5 MG

Price$ 325.00
  • SKU: K-2600-5MG
  • Pack Size: 5 MG

(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione; FR-900494






Kifunensine is historically isolated from Kitasatosporia kifunense. It acts as an inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.

Inhibition of endoplasmic reticulum a-mannosidase I activity rescues the human a-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair a-sarcoglycan trafficking. Improves maturation of misfolded proteins.


Research or further manufacturing use only, not for food or drug use.

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