Soluble in DMSO
Synonym: 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2
Isozyme-selective-Akt inhibitor is a cell-permeable, potent and selective inhibitor of Akt1/Akt2 activity (IC = 58 nM (Akt1), 210 nM (Akt2) and 2.12 M (Akt3) in vitro kinase assays. The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akt's, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 M).
Research or further manufacturing use only, not for food or drug use.