DMSO (100 mM) and Ethanol (50 mM)
A potent, selective and ATP-competitive inhibitor of ATM Kinase (K = 2.2 nM; IC= 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC= 2500, 9300, 16600, 100000 and 100000 nM, respectively). KU-55933 inhibits cancer cell proliferation by inducing G(1) cell-cycle arrest. Sensitizes cells to ionizing radiations and chemotherapeutics. Induces apoptosis in breast and prostate cancer cell lines.
Research or further manufacturing use only, not for food or drug use.