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Price$ 132.68
  • SKU: C-2264-1MG
  • Pack Size: 1 MG



Soluble in DMSO (10 mg/ml)


A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC= 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC= 12 M and 17 M, respectively) and only weakly affects the activities of a panel of 31 kinases ( 25% inhibition at 10 M), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from -irradiation-induced apoptosis with an ECof 3 M and 7.6 M, respectively.

0.1 lbs

Research or further manufacturing use only, not for food or drug use.

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