186692-46-6
354.5
C19H26N6O
Soluble in chloroform (50mg/ml), ethanol or warm DMSO @ (10mg/ml), or methanol; moderately soluble in water.
-20°C
Potent and selective inhibitor of cyclin-dependent kinases (cdks). Selective for CDK1, CDK2, and CDK5.A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis.Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of -Defensins.Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages.Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
